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About afabicin Afabicin (Debio 1450) is Debiopharm's first-in-class FabI inhibitor against Staphylococcus spp., whose sub-class Methicillin-resistant Staphylococcus aureus (MRSA) is high on the WHO global priority pathogen list and deemed a "serious threat" by the CDC. Afabicin can be administered orally or IV and selectively targets Staphylococcus' essential bacterial fatty acid biosynthesis. Promising results have been obtained in a comparative double-blind Phase 2 trial with afabicin in acute bacterial skin and skin structure infections. Currently, an international Phase 2 trial in bone and joint infections is being conducted comparing afabicin to standard antibiotics. About Debio 1453 and Debio 1454S Analogous to Afabicin, the preclinical compounds Debio 1453 and Debio 1454S are potential first in class pathogen-specific drugs targeting the essential bacterial fatty acid biosynthesis. Debio 1453 can be administered orally or intramuscularly to treat Neisseria gonorrhoeae infections while Debio 1454S is being developed for IV use in cases of hospital-acquired pneumonia and ventilator-associated pneumonia caused by carbapenem-resistant Acinetobacter baumannii. Debiopharm's fight against antimicrobial resistance Debiopharm, an innovation-focused, Swiss biopharmaceutical company is one of the few privately owned companies developing novel class antibiotics to combat hard-to-treat infections. Through their unique partnership-based business model, the company is advancing pathogen-specific antibiotics from early stage through phase II clinical research with afabicin, specifically targeting staphylococci, being the most clinically advanced for the treatment of bone and joint infections. As a result of high selectivity, FabI inhibitors specifically target selected pathogens while preserving intestinal microbiota and meet all four WHO 2020 innovation criteria: new chemical class, new target, new mode of action and no cross-resistance to other antibiotic classes. For more information, please visit www.debiopharm.com We are on Twitter. Follow us @DebiopharmNews at http://twitter.com/DebiopharmNews Debiopharm Contact Dawn Haughton Communication Manager dawn.haughton@debiopharm.com Tel: +41 (0)21 321 01 11 References [1] Antimicrobial Resistance Collaborators. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet. 2022;399(10325):629-655. [2] CDC Antibiotic resistance threats in the United States, 2019. https://www.cdc.gov/drugresistance/pdf/threats-report/2019-ar-threats-report-508.pdf [3] Cassini A, et al. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis. Lancet Infect Dis. 2019;19(1):56-66. [4] CDC Antibiotic resistance threats in the United States, 2013. https://www.cdc.gov/drugresistance/pdf/ar-threats-2013-508.pdf ------------------------------------------------------------------- Az OTS internetes oldalán található hírek, közlemények, fotók a forrásmegjelöléssel (OTS) szabadon és korlátozás nélkül felhasználhatók. Továbbközlés esetén a közzétevő köteles az átvett anyagot tartalmának torzítása nélkül, félreérthetőséget, rosszindulatú következtetéseket kizáró, az eredeti szövegkörnyezetnek megfelelő módon feldolgozni és megjelentetni. Az OTS hírek nem képezik az MTI hírkiadás részét, az MTI által szó szerint továbbított tartalomért minden esetben a beadó a felelős. © Copyright MTI nonprofit Zrt. Az OTS szolgáltatással kapcsolatban további információt a (06-1) 441-9050 telefonszámon vagy a ots@mti.hu elektronikus levelező címen kaphat.